宋蕊,张志云,顾志霞,谢美莲,陈梓宁,韩世浩,赵志诚,孟竹,鲁永浩,金荣华

• 1:首都医科大学附属北京地坛医院
• 2:北京邮电大学
• 3:北京微芯区块链与边缘计算研究院

摘要(Abstract)：

目的 基于可穿戴设备探讨新型冠状病毒（新冠病毒）感染者的体征特点及其与疾病病程演变的相关性。方法 采集首都医科大学附属北京地坛医院2022年4月至2022年10月诊治并成功佩戴可穿戴设备的229例新冠病毒感染者的体征数据，包括静息心率、脉搏血氧饱和度（pulse oxygen saturation,SpO_2）和体表温度，以同时期隔离点监测的332例非感染者作为对照组，比较两组的体征信息和基本人口学资料。同时，进一步分析不同临床分型新冠病毒感染者的体征差异，并采用Pearson相关性分析来评估体征与新冠病毒核酸检测循环数阈值（cycle threshold value,Ct值）动态变化的相关性。结果 与对照组比较，病例组静息心率更高[（70.05±6.57）次/min比（66.64±5.44）次/min, t=4.48, P<0.01], SpO_2更低[（97.93±0.30）%比（98.04±0.24）%, t=-2.82, P=0.005）]，体表温度更高[（35.37±0.75）℃比（34.68±0.62）℃，t=7.64,P<0.01]；在病例组中，相对于无症状/轻型组，普通型组静息心率更高[（72.55±7.85）次/min比（68.69±5.27）次/min, t=-3.00, P=0.003], SpO_2更低[（97.80±0.34）%比（98.01±0.24）%,t=3.74,P<0.01]，体表温度更高[（35.69±0.49）℃比（35.19±0.81）℃，t=-3.48,P<0.01]；病例组的心率和SpO_2与核酸Ct值存在相关性，心率与Ct值（N基因和ORF1ab基因）呈负相关（N基因r=-0.43,ORF1ab基因r=-0.45,P均=0.020）,SpO_2与Ct值呈正相关（N基因r=0.33,ORF1ab基因r=0.34,P均=0.010）。结论 新冠病毒感染者静息心率更高、SpO_2更低、体表温度更高，不同临床分型的感染者体征存在差异，且上述体征变化与其病情发展呈现一定相关性，患者在新冠病毒感染过程中可尝试佩戴可穿戴设备以及时自我监测病情。

关键词(KeyWords)： 新型冠状病毒感染;可穿戴设备;静息心率;脉搏血氧饱和度;体表温度;核酸循环数阈值

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划项目(2021YFC0863300);; 首都卫生发展科研专项项目(2022-1-2171);; 北京市科技计划项目(Z211100002521015,Z221100007922007);; 北京市医院管理中心“扬帆计划”项目(XMLX202149)

作者(Author): 宋蕊,张志云,顾志霞,谢美莲,陈梓宁,韩世浩,赵志诚,孟竹,鲁永浩,金荣华

DOI: 10.16505/j.2095-0136.2025.0002

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